The R33 Skyline (Series 2) continued the concepts introduced in the R32. Drivers airbags became standard in 1996 as they had been only an option up until this time, passenger side airbags remained an option. For the RB25DET engine the ignition system was also changed, with the ignition module no longer located on the cam covers and was instead replaced by smart ignition coils (Ignitor built into coil) and ECU. The RB25DET turbo was also given a nylon compressor wheel. Throughout the time the R33 was produced there were quite a number of different styled lights and bodykits fitted, the actual body/chassis underwent no changes. Among the cosmetic changes in the series 2 were, the headlights which tapered down more towards the grill and were fitted with improved reflectors, the grill (which was longer on the Series 1), the bonnet which had a re-shaped leading edge to fit the new lights and front bumper changing shape in the smallest amount to match the lower edge of the new headlights. Later models of the Series 2 also had the option of having a Active-LSD fitted. The R33 ceased production in March 1998 with the 40th Anniversary R33 Series 2.

The R33 Skyline was introduced in August 1993. Slightly heavier than the R32, and available as a 2 and 4 door, all models now used a 6-cylinder engine. Nissan took the unusual step of down grading the GTS model to have only the RB20E, while the twin-cam of the R32 GTS was discontinued along with the 2.0 L turbo RB20DET. As with the R32, all auto transmissions on the 2.5 litre non turbo models were 5 speed, all 2 litre and turbo 2.5 litre automatic models were equipped with a 4 speed auto transmission.

Some models came equipped with a new version of the HICAS 4-wheel steering system called Super HICAS. This computer controlled system was first used on the R32 GTR. Super HICAS used electric actuators to steer the rear, as opposed to the hydraulic HICAS.

As an option, an active limited slip differential was available instead of the standard viscous LSD. This new unit locked the rear differential if it detected that traction was lost by one of the wheels. A light on the dash also lit up if the LSD engaged. Active LSD came standard on all V-spec R33 GT-R Skylines and was also available on a certain amount of ECR33 GtS25T models, these can be identified by the A-LSD and SLIP lights on the tachometer.

The RB25DE and RB25DET engines also became equipped with NVCS (variable inlet cam phasing). NVCS equipped RBs have a bulge on the front of the cam cover. To celebrate their 40th anniversary, Nissan introduced a very rare 4 door GT-R. Two versions of the 4-door GT-R were available from Nissan's subsidiaries: the first was produced by Autech, and the second was a joint Autech/Nismo project.

A R33 based wagon was released in September 1996, called the Stagea. It had a different body style than the R33 and R34 and (with the exception of the RS FOUR & Autech variants) was only available with an automatic transmission. A common modification on the Stagea is to fit it with an R34 skyline front, in effect making a 4 door R34 wagon. The Stagea is the only four wheel drive manual transmission Nissan on the R33 platform with the RB25DET engine. Presumably, a 5 speed 4WD Skyline equipped with an RB25DET would have been too close in performance to the much more expensive GT-R. There was also an Autech Stagea, the 260RS released with full GT-R running gear, the RB26DETT engine, body kit, 17" BBS style alloys, GT-R instrumentation, and manual transmission.[9]

R33 models:
HR33 GTS - 2.0 L RB20E SOHC I6, 130 PS (96 kW, 172 N m)
ER33 GTS25 - 2.5 L RB25DE DOHC I6, 190 PS (140 kW, 231 N m)
ENR33 GTS-4 - 2.5 L RB25DE DOHC I6, 190 PS (140 kW, 231 N m) 4WD
ECR33 GTS25T - 2.5 L RB25DET DOHC turbo I6, 250 PS (184 kW, 294 N m)